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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as a focus on the practical aspects of designing a study that include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and had participants from different geographic areas. This kind of heterogeneity, that is crucial for a pragmatic trial to be valid and lessen the chance of bias, is also necessary. However, too much heterogeneity, can cause problems with the trial design.

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Pragmatic Play is known for its top-quality games and also for providing an outstanding user experience. The software is available on mobile devices and in multiple languages. Despite its relatively young age it has already established itself as a top casino gaming platform. The most recent releases include Wolves which is a five-reel video slot with a healthful RTP and 프라그마틱 슬롯 stunning graphics. Other notable games include Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. They are usually commissioned by policymakers and practitioners in order to guide their decisions. They are also a good method to determine the cause-effect relationship between the intervention and its effects. They should not, however be used to replace the need for explanation studies.

The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace tests for explanations or if they should serve as an addition to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm a physiological or clinical hypothesis and pragmatic trials, which guide policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study that includes recruitment, design, implementation of the intervention and its follow-up.

There is a growing increase in the number pragmatic trials that have been published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to note, however, that the majority were conducted in primary-care settings.